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Authors
Affiliations
1 Airlangga University, Jl. Dharmawangsa Dalam Surabaya 60286, ID
2 School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha No. 10, Bandung 40132, ID
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 1 (2017), Pagination: 33-36
Abstract
Objective of the study is to characterize acyclovir-nicotinamide binary systems (AN). Methods of cocrystallization was solvent evaporation in equimolar ratio between acyclovir and nicotinamide using ethanol and methanol. The binary systems were characterized by polarization microscope, Differential Scanning Calorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Physical characterization showed that AN binary systems have unique crystal habit in microscopic. A new endothermic peak appears at 123.69°C. The PXRD patterns of AN binary systems after cocrystallization are different from pure components which specific peak was found on 2θ = 11.27° (AN in ethanol); 21.05° (AN in methanol).
Keywords
Acyclovir, Nicotinamide, Binary Systems, Solvent Evaporation, Ethanol, Methanol.
